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Omics score: 118

Homo sapiens

ABSTRACT: microRNA profiling of four DLD1 colorectal cancer cell derivatives that recapitulate EMT/MET transitions during metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: PRJNA339109 | ENA |

REPOSITORIES: ENA

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Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis.

Rokavec Matjaz M Horst David D Hermeking Heiko H

Cancer research 20170127 8

Here, we developed and comprehensively characterized a cellular model of colon cancer progression consisting of four defined derivatives of a colon cancer cell line that resulted from consecutive epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT/MET) and phenotypically recapitulate the metastatic cascade. Initial EMT was induced by prolonged exposure to IL6, a cytokine also generated by the tumor-stroma. Genome-wide characterization of transcriptional (mRNA, miRNA, and lncRNA) a ...[more]

PMID: 28130225

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