Genomics

Dataset Information

294

Mus musculus


ABSTRACT: A distinct gene module uncouples dysfunction from activation in tumor-infiltrating T cells (part 1)

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA339824 | ENA |

REPOSITORIES: ENA

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Publications


Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is the focus of therapeutic interventions; however, current therapies are effective in only some patients and some tumor types. To gain a deeper molecular understanding of the dysfunctional T cell state, we analyzed population and single-cell RNA profiles of CD8(+) tumor-infiltrating lymphocytes (TILs) and used genetic perturbations to identify a distinct gene module for T cell dysfunction that can be unc  ...[more]

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