Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA339836 | ENA |

REPOSITORIES: ENA

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Publications

Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype.

Price Aryn A AA   Tedesco Dana D   Prasad Mona R MR   Workowski Kimberly A KA   Walker Christopher M CM   Suthar Mehul S MS   Honegger Jonathan R JR   Grakoui Arash A  

Proceedings of the National Academy of Sciences of the United States of America 20160906 38


Maternal innate and adaptive immune responses are modulated during pregnancy to concurrently defend against infection and tolerate the semiallogeneic fetus. The restoration of these systems after childbirth is poorly understood. We reasoned that enhanced innate immune activation may extend beyond gestation while adaptive immunity recovers. To test this hypothesis, the transcriptional profiles of total peripheral blood mononuclear cells following delivery in healthy women were compared with those  ...[more]

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