Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Comprehensive mapping of 5-hmC epigenetic dynamics in axon regeneration

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA339858 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration.

Loh Yong-Hwee Eddie YE   Koemeter-Cox Andrew A   Finelli Mattéa J MJ   Shen Li L   Friedel Roland H RH   Zou Hongyan H  

Epigenetics 20161205 2


In contrast to central nervous system neurons, dorsal root ganglia (DRG) neurons can switch to a regenerative state after peripheral axotomy. In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we identified Tet methylcytosine dioxygenase 3 (Tet3) as upregulated in DRG neurons, along with increased 5-hydroxymethylcytosine (5hmC). We generated genome-wide 5hmC maps in adult DRG, which revealed that peripheral and central axotomy (leading to no  ...[more]

Similar Datasets

2012-09-30 | E-GEOD-40539 | ArrayExpress
2014-12-04 | E-GEOD-61417 | ArrayExpress
2014-05-01 | E-GEOD-54089 | ArrayExpress
| GSE115454 | GEO
2012-09-18 | E-GEOD-38231 | ArrayExpress
| GSE85972 | GEO
2011-10-30 | E-GEOD-32050 | ArrayExpress
2014-03-15 | E-GEOD-55934 | ArrayExpress
2011-01-06 | GSE21746 | GEO
2016-09-01 | E-GEOD-77967 | ArrayExpress