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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

ABSTRACT: The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

PROVIDER: PRJNA340144 | ENA |

REPOSITORIES: ENA

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

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Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Macaque_450k]

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

Project description:We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. The replicated aDMPs show a faster rate of change with age in the shorter lived dog species. Strikingly, these aDMPs also show a faster rate of change with age in dogs overall compared with humans.

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

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Project description:We used blood samples from Macaque to determine rate of change of methylation with respect to age.

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

Project description:We used liver samples from TC1 Mice to determine rate of change of methylation with respect to age.

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Project description:We used liver samples from Naked Mole Rat to determine rate of change of methylation with respect to age.

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

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Ageing transcriptomes of selected mutants on different carbon sources

Project description:Here we show that an unrestricted galactose diet in early life minimises pathology during replicative ageing in budding yeast, irrespective of diet later in life. Lifespan and average mother cell division rate are comparable between glucose and galactose diets, but markers of senescence and the progressive dysregulation of gene expression observed on glucose are minimal on galactose, showing these to be facets of ageing pathology rather than intrinsic parts of the replicative ageing process. Respiration on galactose is critical for minimising ageing pathology, and forced respiration during ageing on glucose by over-expression of Hap4 also has the same effect though only in a fraction of cells. This fraction maintains Hap4 activity to advanced age with low senescence and a youthful gene expression profile, whereas other cells in the same population that lose Hap4 activity undergo dramatic dysregulation of gene expression and accumulate aneuploid fragments of chromosome XII aneuploidy (ChrXIIr), which are tightly associated with ageing pathology.

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