Dataset Information
Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA340414 | ENA |
REPOSITORIES: ENA
Publications
Modeling and high-throughput experimental data uncover the mechanisms underlying <i>Fshb</i> gene sensitivity to gonadotropin-releasing hormone pulse frequency.
The Journal of biological chemistry 20170406 23
Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms. GnRH regulates the pituitary gonadotropin's follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique β subunits (FSHβ/LHβ). Contrary to <i>Lhb</i>, <i>Fshb</i> gene induction has a preference for low-frequency GnRH pulses. To clarify the underlying regula ...[more]