Project description:BORIS expresses abnormally in colorectal cancer cells. Both the expression and the copy number of BORIS are remarkably higher in colorectal cancer cells than in normal colon or rectal cells. BORIS is potential diagnosis, prognosis or therapeutic target for colorectal cancer. To expand our view of the signaling pathway related with BORIS, altered gene expression by BORIS knockdown was assessed by microarray assay. To study the gene regulation by BORIS knockdown, microarray assay was applied to screen the gene expression regulated by BORIS siRNA in colorectal cancer cells HCT116 and Caco-2
Project description:We have demonstrated that ELK4 promted progression and tumorigenesis in colorectal cancer. In order to elucidate the transcriptional regulation mechanism of ELK4 in colorectal cancer, RNA-seq analysis was performed on ELK4 knockdown and control HCT116 cells.
