Genomics

Dataset Information

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Gallus gallus


ABSTRACT: Effect of Notch signal inhibition on chicken neural retina in spreading culture

ORGANISM(S): Gallus gallus  

PROVIDER: PRJNA341227 | ENA |

REPOSITORIES: ENA

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Publications

Intrinsic lens potential of neural retina inhibited by Notch signaling as the cause of lens transdifferentiation.

Iida Hideaki H   Ishii Yasuo Y   Kondoh Hisato H  

Developmental biology 20161111 2


Embryonic neural retinas of avians produce lenses under spreading culture conditions. This phenomenon has been regarded as a paradigm of transdifferentiation due to the overt change in cell type. Here we elucidated the underlying mechanisms. Retina-to-lens transdifferentiation occurs in spreading cultures, suggesting that it is triggered by altered cell-cell interactions. Thus, we tested the involvement of Notch signaling based on its role in retinal neurogenesis. Starting from E8 retina, a smal  ...[more]

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