Dataset Information


Homo sapiens

ABSTRACT: Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia



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Targeting the vulnerability to NAD<sup>+</sup> depletion in B-cell acute lymphoblastic leukemia.

Takao S S   Chien W W   Madan V V   Lin D-C DC   Ding L-W LW   Sun Q-Y QY   Mayakonda A A   Sudo M M   Xu L L   Chen Y Y   Jiang Y-Y YY   Gery S S   Lill M M   Park E E   Senapedis W W   Baloglu E E   Müschen M M   Koeffler H P HP  

Leukemia 20170914 3

Although substantial progress has been made in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), the prognosis of patients with either refractory or relapsed B-ALL remains dismal. Novel therapeutic strategies are needed to improve the outcome of these patients. KPT-9274 is a novel dual inhibitor of p21-activated kinase 4 (PAK4) and nicotinamide phosphoribosyltransferase (NAMPT). PAK4 is a serine/threonine kinase that regulates a variety of fundamental cellular processes. NAMPT is a r  ...[more]

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