Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA343282 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:NHLBI TOPMed: San Antonio Family Heart Study (SAFHS)
| PRJNA343281 | ENA
Project description:There is growing evidence that genomic DNA sequence changes occur in individual somatic cells during the lifetime of an individual and accumulation of these changes may influence aging and disease. In light of this, and contradicting reports regarding discordant copy number profiles between MZ twins(BARANZINI et al. 2010; BRUDER et al. 2008), we set out to identify de novo somatic copy number mutations in DNA from blood for MZ twin pairs of Mexican American descent who were participants of the San Antonio Family Heart Study (SAFHS) or San Antonio Family Diabetes/Gallbladder study (SAFDGS). By applying circular binary segmentation (CBS) to B-allele ratio differences we determined that the 3 MZ twin pairs in this study had concordant copy number profiles. We also detected 2 de novo germ-line CNVs in 2 MZ twin pairs from the SAFHS.
2010-12-11 | GSE25826 | GEO
Project description:T2D-GENES: San Antonio Mexican American Family Studies (SAMAFS)
| PRJNA269204 | ENA
Project description:T2D-GENES: San Antonio Mexican American Family Studies (SAMAFS)
| PRJNA269203 | ENA
Project description:NHLBI TOPMed: The Cleveland Family Study
| PRJNA290940 | ENA
Project description:There is growing evidence that genomic DNA sequence changes occur in individual somatic cells during the lifetime of an individual and accumulation of these changes may influence aging and disease. In light of this, and contradicting reports regarding discordant copy number profiles between MZ twins(BARANZINI et al. 2010; BRUDER et al. 2008), we set out to identify de novo somatic copy number mutations in DNA from blood for MZ twin pairs of Mexican American descent who were participants of the San Antonio Family Heart Study (SAFHS) or San Antonio Family Diabetes/Gallbladder study (SAFDGS). By applying circular binary segmentation (CBS) to B-allele ratio differences we determined that the 3 MZ twin pairs in this study had concordant copy number profiles. We also detected 2 de novo germ-line CNVs in 2 MZ twin pairs from the SAFHS. This study includes data for 4 monozygotic (MZ) twin pairs, and both parents of 2 of these MZ twin pairs. The purpose of this study was to compare concordance of copy number profiles between MZ twins.
2010-12-11 | E-GEOD-25826 | biostudies-arrayexpress