Genomics

Dataset Information

118

PU.1


ABSTRACT: PU.1

PROVIDER: PRJNA344317 | ENA |

REPOSITORIES: ENA

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Publications

PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development.

Batista Carolina R CR   Li Stephen K H SK   Xu Li S LS   Solomon Lauren A LA   DeKoter Rodney P RP  

Journal of immunology (Baltimore, Md. : 1950) 20170106 4


B cell development and Ig rearrangement are governed by cell type- and developmental stage-specific transcription factors. PU.1 and Spi-B are E26-transformation-specific transcription factors that are critical for B cell differentiation. To determine whether PU.1 and Spi-B are required for B cell development in the bone marrow, Spi1 (encoding PU.1) was conditionally deleted in B cells by Cre recombinase under control of the Mb1 gene in Spib (encoding Spi-B)-deficient mice. Combined deletion of S  ...[more]

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