Genomics

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Emerging role of polycomb repressive complex 2 in the early neuroblastoma tumorigenesis in TH-MYCN transgenic mice and its association with human neuroblastoma


ABSTRACT: Emerging role of polycomb repressive complex 2 in the early neuroblastoma tumorigenesis in TH-MYCN transgenic mice and its association with human neuroblastoma

PROVIDER: PRJNA347581 | ENA |

REPOSITORIES: ENA

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Publications

PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma.

Tsubota Shoma S   Kishida Satoshi S   Shimamura Teppei T   Ohira Miki M   Yamashita Satoshi S   Cao Dongliang D   Kiyonari Shinichi S   Ushijima Toshikazu T   Kadomatsu Kenji K  

Cancer research 20170814 19


Pediatric cancers such as neuroblastoma are thought to involve a dysregulation of embryonic development. However, it has been difficult to identify the critical events that trigger tumorigenesis and differentiate them from normal development. In this study, we report the establishment of a spheroid culture method that enriches early-stage tumor cells from TH-MYCN mice, a preclinical model of neuroblastoma. Using this method, we found that tumorigenic cells were evident as early as day E13.5 duri  ...[more]

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