Dataset Information


Homo sapiens

ABSTRACT: Impairment of host liver repopulation by transplanted hepatocytes in aged rats and the release by short-term growth hormone treatment

ORGANISM(S): Homo sapiens  



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Impairment of Host Liver Repopulation by Transplanted Hepatocytes in Aged Rats and the Release by Short-Term Growth Hormone Treatment.

Stock Peggy P   Bielohuby Maximilian M   Staege Martin S MS   Hsu Mei-Ju MJ   Bidlingmaier Martin M   Christ Bruno B  

The American journal of pathology 20170112 3

Hepatocyte transplantation is an alternative to whole liver transplantation. Yet, efficient liver repopulation by transplanted hepatocytes is low in livers of old animals. This restraint might be because of the poor proliferative capacity of aged donor hepatocytes or the regenerative impairment of the recipient livers. The age-dependent liver repopulation by transplanted wild-type hepatocytes was investigated in juvenile and senescent rats deficient in dipeptidyl-peptidase IV. Repopulation was q  ...[more]

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