Genomics

Dataset Information

0

Schizosaccharomyces pombe


ABSTRACT: Replication origin mapping of cdc25-22 and Cdc13-Cdc2 cells after G2 block

ORGANISM(S): Schizosaccharomyces pombe  

PROVIDER: PRJNA348343 | ENA |

REPOSITORIES: ENA

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Publications

CDK activity provides temporal and quantitative cues for organizing genome duplication.

Perrot Anthony A   Millington Christopher Lee CL   Gómez-Escoda Blanca B   Schausi-Tiffoche Diane D   Wu Pei-Yun Jenny PJ  

PLoS genetics 20180221 2


In eukaryotes, the spatial and temporal organization of genome duplication gives rise to distinctive profiles of replication origin usage along the chromosomes. While it has become increasingly clear that these programs are important for cellular physiology, the mechanisms by which they are determined and modulated remain elusive. Replication initiation requires the function of cyclin-dependent kinases (CDKs), which associate with various cyclin partners to drive cell proliferation. Surprisingly  ...[more]

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