Dataset Information


Homo sapiens

ABSTRACT: Real-time quantitative PCR analysis of human T cells

ORGANISM(S): Homo sapiens  



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MicroRNA expression profiles in human CD3+ T cells following stimulation with anti-human CD3 antibodies.

Sousa Isabel Garcia IG   do Almo Manuela Maragno MM   Simi Kelly Cristina Rodrigues KC   Bezerra Maryani Andressa Gomes MA   Andrade Rosângela Vieira RV   Maranhão Andréa Queiroz AQ   Brigido Marcelo Macedo MM  

BMC research notes 20170314 1

Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely clear. In T cells, microRNAs (miRNAs) regulate several pathways, including those associated with immune tolerance. Here, we report changes in miRNA expression in T cells following treatment with anti-human CD3 antibodies. Peripheral blood mononuclear cells we  ...[more]

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