Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Conversion of adult endothelium to immunocompetent haematopoietic stem cells

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA348758 | ENA |

REPOSITORIES: ENA

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Publications


Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient expression of the transcription-factor-encoding genes Fosb, Gfi1, Runx1, and Spi1 (collectively denoted hereafter as FGRS) and vascular-niche-derived angiocrine factors. The induction phase (days 0-8) of conversio  ...[more]

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