Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Exosome-mediated transfer of cardio-protective miRNAs between cardiomyocytes prevents apoptosis induced by hypoxia

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA354448 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5043184.fastq.gz Fastqsanger.gz
SRR5043185.fastq.gz Fastqsanger.gz
SRR5043186.fastq.gz Fastqsanger.gz
SRR5043187.fastq.gz Fastqsanger.gz
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Publications

Overexpression of Exosomal Cardioprotective miRNAs Mitigates Hypoxia-Induced H9c2 Cells Apoptosis.

Zhang Jinwei J   Ma Jideng J   Long Keren K   Qiu Wanling W   Wang Yujie Y   Hu Zihui Z   Liu Can C   Luo Yi Y   Jiang Anan A   Jin Long L   Tang Qianzi Q   Wang Xun X   Li Xuewei X   Li Mingzhou M  

International journal of molecular sciences 20170328 4


Recent evidence suggests that hypoxia caused by acute myocardial infarction can induce cardiomyocyte apoptosis. Exosomes are signalling mediators that contribute to intercellular communication by transporting cytosolic components including miRNAs, mRNAs, and proteins. However, the systemic regulation and function of exosomal miRNAs in hypoxic cardiomyocytes are currently not well understood. Here, we used small RNA sequencing to investigate the effects of hypoxia stress on miRNAome of rat cardio  ...[more]

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