Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Analysis of transcriptional and epigentic changes induced by loss of Phf8 [RNA-seq]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA354483 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5032660.fastq.gz Fastqsanger.gz
SRR5032670.fastq.gz Fastqsanger.gz
SRR5032651.fastq.gz Fastqsanger.gz
SRR5032661.fastq.gz Fastqsanger.gz
SRR5032671.fastq.gz Fastqsanger.gz
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Publications


PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored. Here, we have generated a Phf8 knockout allele in mice to examine the consequences of Phf8 loss for development and behaviour. Phf8 deficient mice neither display obvious developmental defects nor signs of cognitive impairment. However, we report a striking resili  ...[more]

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