Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: Transcriptome-wide identification of IGF2BP binding RNAs by RIP-seq.

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA355266 | ENA |

REPOSITORIES: ENA

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Publications


N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. In contrast to the mRNA-decay-promoting function of YTH domain-contain  ...[more]

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