Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL [ATAC-Seq]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA355312 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5061714.fastq.gz Fastqsanger.gz
SRR5061715.fastq.gz Fastqsanger.gz
SRR5061716.fastq.gz Fastqsanger.gz
SRR5061717.fastq.gz Fastqsanger.gz
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Publications


Inactivation of the tumor suppressor gene encoding the transcriptional regulator Ikaros (<i>IKZF1</i>) is a hallmark of BCR-ABL1<sup>+</sup> precursor B cell acute lymphoblastic leukemia (pre-B ALL). However, the mechanisms by which Ikaros functions as a tumor suppressor in pre-B ALL remain poorly understood. Here, we analyzed a mouse model of BCR-ABL1<sup>+</sup> pre-B ALL together with a new model of inducible expression of wild-type Ikaros in <i>IKZF1</i> mutant human BCR-ABL1<sup>+</sup> pre  ...[more]

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