Genomics

Dataset Information

0

Mus musculus


ABSTRACT: RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA356248 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5076780_1.fastq.gz Fastqsanger.gz
SRR5076780_2.fastq.gz Fastqsanger.gz
SRR5076777_1.fastq.gz Fastqsanger.gz
SRR5076777_2.fastq.gz Fastqsanger.gz
SRR5076778_1.fastq.gz Fastqsanger.gz
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Publications

RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis.

Mooney Claire M CM   Jimenez-Mateos Eva M EM   Engel Tobias T   Mooney Catherine C   Diviney Mairead M   Venø Morten T MT   Kjems Jørgen J   Farrell Michael A MA   O'Brien Donncha F DF   Delanty Norman N   Henshall David C DC  

Scientific reports 20170127


The nonsense mediated decay (NMD) pathway is a critical surveillance mechanism for identifying aberrant mRNA transcripts. It is unknown, however, whether the NMD system is affected by seizures in vivo and whether changes confer beneficial or maladaptive responses that influence long-term outcomes such the network alterations that produce spontaneous recurrent seizures. Here we explored the responses of the NMD pathway to prolonged seizures (status epilepticus) and investigated the effects of NMD  ...[more]

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