Genomics

Dataset Information

118

Saccharomyces cerevisiae


ABSTRACT: Study of ribosome dynamics after eIF5A depletion in budding yeast

ORGANISM(S): Saccharomyces cerevisiae  

PROVIDER: PRJNA356767 | ENA |

REPOSITORIES: ENA

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Publications

eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences.

Pelechano Vicent V   Alepuz Paula P  

Nucleic acids research 20170701 12


eIF5A is an essential protein involved in protein synthesis, cell proliferation and animal development. High eIF5A expression is observed in many tumor types and has been linked to cancer metastasis. Recent studies have shown that eIF5A facilitates the translation elongation of stretches of consecutive prolines. Activated eIF5A binds to the empty E-site of stalled ribosomes, where it is thought to interact with the peptidyl-tRNA situated at the P-site. Here, we report a genome-wide analysis of r  ...[more]

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