Dataset Information


Mus musculus

ABSTRACT: Copy number alteration in Murine Tumor Cells: primary inoculated tumor cells vs. out-growing tumor cells [Fig7b]

ORGANISM(S): Mus musculus  



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IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting.

Takeda Kazuyoshi K   Nakayama Masafumi M   Hayakawa Yoshihiro Y   Kojima Yuko Y   Ikeda Hiroaki H   Imai Naoko N   Ogasawara Kouetsu K   Okumura Ko K   Thomas David M DM   Smyth Mark J MJ  

Nature communications 20170224

Genetic evolution that occurs during cancer progression enables tumour heterogeneity, thereby fostering tumour adaptation, therapeutic resistance and metastatic potential. Immune responses are known to select (immunoedit) tumour cells displaying immunoevasive properties. Here we address the role of IFN-γ in mediating the immunoediting process. We observe that, in several mouse tumour models such as HA-expressing 4T1 mammary carcinoma cells, OVA-expressing EG7 lymphoma cells and CMS5 MCA-induced  ...[more]

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