Dataset Information


Mus musculus

ABSTRACT: Oncogene-induced senescence in primary mouse keratinocytes

ORGANISM(S): Mus musculus  



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The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.

Ritschka Birgit B   Storer Mekayla M   Mas Alba A   Heinzmann Florian F   Ortells Mari Carmen MC   Morton Jennifer P JP   Sansom Owen J OJ   Zender Lars L   Keyes William M WM  

Genes & development 20170131 2

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory phenotype (SASP), which can reinforce the arrest and induce senescence in a paracrine manner. However, the SASP has also been shown to favor embryonic development, wound healing, and even tumor growth, suggesting more complex physiological roles than currently understood. Here  ...[more]

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