Project description:17β-estradiol (E2) pollution has attracted much attention, and the existence of E2 poses certain risks to the environment and human health. However, the mechanism of microbial degradation of E2 remains unclear. In this study, the location of E2-degrading enzymes was investigated, and transcriptome analysis of Microbacterium resistens MZT7 (M. resistens MZT7) exposed to E2. The degradation of E2 by M. resistens MZT7 was via the biological action of E2-induced intracellular enzymes. With the RNA sequencing, we found 1,109 differentially expressed genes (DEGs). Among, 773 genes were up-regulated and 336 genes were down-regulated. The results of the RNA sequencing indicated the DEGs were related to transport, metabolism, and stress response. Genes for transport, transmembrane transport, oxidoreductase activity, ATPase activity, transporter activity and quorum sensing were up-regulated. Genes for tricarboxylic acid cycle, ribosome, oxidative phosphorylation and carbon metabolism were down-regulated. These findings provide some new insights into the molecular mechanism of biotransformation of E2 by M. resistens MZT7.

2022-08-24 | GSE211838 | GEO

Flavobacterium micromati strain:DSM 17659 | isolate:DSM 17659

Project description:Flavobacterium micromati DSM 17659 genome sequencing

| PRJNA335175 | ENA

Flavobacterium degerlachei strain:DSM 15718 | isolate:DSM 15718

Project description:Flavobacterium degerlachei DSM 15718 genome sequencing

| PRJNA335176 | ENA

Flavobacterium akiainvivens strain:DSM 25510 | isolate:DSM 25510

Project description:Flavobacterium akiainvivens DSM 25510 genome sequencing

| PRJNA331408 | ENA

Flavobacterium xanthum strain:DSM 3661 | isolate:DSM 3661

Project description:Flavobacterium xanthum DSM 3661 genome sequencing