Genomics

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118

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators


ABSTRACT: Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

PROVIDER: PRJNA376803 | ENA |

REPOSITORIES: ENA

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Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.

Liu Nian N   Lee Cameron H CH   Swigut Tomek T   Grow Edward E   Gu Bo B   Bassik Michael C MC   Wysocka Joanna J  

Nature 20171206 7687


Transposable elements, also known as transposons, are now recognized not only as parasitic DNA, the spread of which in the genome must be controlled by the host, but also as major players in genome evolution and regulation. Long interspersed element-1 (LINE-1, also known as L1), the only currently autonomous mobile transposon in humans, occupies 17% of the genome and generates inter- and intra-individual genetic variation, in some cases resulting in disease. However, how L1 activity is controlle  ...[more]

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