Genomics

Dataset Information

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Streptomyces coelicolor


ABSTRACT: Zinc-dependent regulation of zinc import and export genes by Zur

ORGANISM(S): Streptomyces coelicolor  

PROVIDER: PRJNA378345 | ENA |

REPOSITORIES: ENA

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Zinc-dependent regulation of zinc import and export genes by Zur.

Choi Seung-Hwan SH   Lee Kang-Lok KL   Shin Jung-Ho JH   Cho Yoo-Bok YB   Cha Sun-Shin SS   Roe Jung-Hye JH  

Nature communications 20170609


In most bacteria, zinc depletion is sensed by Zur, whereas the surplus is sensed by different regulators to achieve zinc homeostasis. Here we present evidence that zinc-bound Zur not only represses genes for zinc acquisition but also induces the zitB gene encoding a zinc exporter in Streptomyces coelicolor, a model actinobacteria. Zinc-dependent gene regulation by Zur occurs in two phases. At sub-femtomolar zinc concentrations (phase I), dimeric Zur binds to the Zur-box motif immediately upstrea  ...[more]

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