Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA378653 | ENA |
REPOSITORIES: ENA
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Project description:screening of signature deterimes the individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells There is paucity of information whether human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) from separate donors might have different effects on improving myocardial repair after myocardial infarction (MI).
2011-02-19 | GSE27414 | GEO
Project description:Quantitative shotgun proteomic analysis (TMT) of the effect of inhibition of MIR21 in the EV protein cargo of human, Umbilical cord-derived Mesenchymal Stem Cells.
2021-02-27 | MSV000086963 | MassIVE
Project description:We performed a proteomic profiling of human mesenchymal stem cells (hMSCs) derived from adipose tissue or umbilical cord.
2018-07-11 | PXD009893 | Pride
Project description:screening of signature deterimes the individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells There is paucity of information whether human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) from separate donors might have different effects on improving myocardial repair after myocardial infarction (MI). We screened cell surface genes by the comparing the cells that showed the best and worst efficacy, respectively, in repairing the infarcted myocardium of rats.
2011-02-19 | E-GEOD-27414 | biostudies-arrayexpress
Project description:Human umbilical cord mesenchymal stem cells maintained multipotency and immunosuppressive ability when being cultured in chemical defined serum free medium, but gained different gene expression profile. We used microarrays to identify the transcriptional difference between human umbilical cord mesenchymal stem cells cultured in serum containing medium and chemical defined serum free medium. human umbilical cord mesenchymal stem cells were cultured in conventional serum containing medium and chemical defined serum free medium separately. Total RNA was extracted and hybridized on Affymetrix microarrays.
2014-10-28 | E-GEOD-62665 | biostudies-arrayexpress
Project description:Discography is an imaging procedure typically performed on patients who report extended periods of pain.Usually radiocontrast agents are used to diagnose the discogenic low back pain. This study was focused on investigating the effects of two clinically used, non-ionic radiocontrast dyes, isovue-370 and omnipaque-240, on the human umbilical cord mesenchymal stem cells (UC-MSCs). Human UC-MSCs were cultured and treated with various concentrations of Omnipaque and Isovue for 24 hr. The cell growth was inhibited by both the dyes. The results showed that both the dyes significantly affected the cell morphology and viability as well as caused apoptosis in UC-MSCs. The global gene expression analysis showed that the most effected genes were those involved in the apoptosis, DNA damage and toxicity.
2017-10-04 | GSE96043 | GEO
Project description:Expression data from human umbilical cord-derived mesenchymal stem cells
| PRJNA382841 | ENA
Project description:As an important part of regenerative medicine, human umbilical cord mesenchymal stem cells show a good clinical therapeutic effect, but their use is still limited. In recent years, the use of umbilical cord mesenchymal stem cell exosomes as cell replacement therapy can effectively overcome some defects of cell therapy. However, whether there are differences among different batches of exosomes, the specific mechanism of exosomes intervention is still poorly known. In this study, LC-MS/MS was used to identify the protein composition of two generations exosomes from three different donors, and the function and possible mechanism of exosome proteomic of human umbilical cord mesenchymal stem cells was analyzed by bioinformatics. It was found that the protein composition of human umbilical cord mesenchymal stem cell exosomes was basically the same in 6 groups, and 676 core proteins were found. The biological function of core proteomic was analyzed by GO, and it was found that core proteomic was involved in 88 molecular functions, such as anion binding, nucleotide binding, receptor binding, ribonucleotide binding; 648 biological processes, such as regulation of cellular process, macromolecule metabolic process, transport; 157 cellular components. The regulation pathway of core proteomic was analyzed by KEGG, and it was found that the regulation of blood coagulation, bacterial infection, phagocytosis, vesicle circulation and so on. Umbilical cord mesenchymal stem cell exosomes were used to interfere with APP/PS1 transgenic mice to explore the mechanism of exosome regulation of synaptic vesicle cycle signal pathway in Alzheimer's disease. The results showed that the exosomes could significantly enhance the spatial memory and learning ability, exercise ability and anti-fatigue ability of Alzheimer's disease model mice. Further analysis of mouse hippocampal proteome showed that the exosome proteomic of human umbilical cord mesenchymal stem cells was enriched into 9 proteins of synaptic vesicle cycle signal pathway. Compared with control group and exosome group, the contents of AP2A1 and AP2B1 in hippocampus of model group were significantly decreased. The results of this study can provide research methods and theoretical basis for the use of human umbilical cord mesenchymal stem cell exosomes to treat diseases, and further promote its clinical application.
2022-11-01 | PXD037877 | iProX
Project description:Human umbilical cord blood-derived mesenchymal stem cells from 2 donors
| PRJNA137237 | ENA
Project description:Shotgun proteomic analysis was performed on lysates from umbilical cord and adjult mesenchymal stem cells
2022-12-19 | PXD032994 | Pride