Dataset Information


Homo sapiens

ABSTRACT: JAK dependent survival of ALK- ALCL

ORGANISM(S): Homo sapiens  



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Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.

Chen Jing J   Zhang Yong Y   Petrus Michael N MN   Xiao Wenming W   Nicolae Alina A   Raffeld Mark M   Pittaluga Stefania S   Bamford Richard N RN   Nakagawa Masao M   Ouyang Sunny Tianyi ST   Epstein Alan L AL   Kadin Marshall E ME   Del Mistro Annarose A   Woessner Richard R   Jaffe Elaine S ES   Waldmann Thomas A TA  

Proceedings of the National Academy of Sciences of the United States of America 20170329 15

Activating Janus kinase (JAK) and signal transducer and activator of transcription (STAT) mutations have been discovered in many T-cell malignancies, including anaplastic lymphoma kinase (ALK)- anaplastic large cell lymphomas (ALCLs). However, such mutations occur in a minority of patients. To investigate the clinical application of targeting JAK for ALK- ALCL, we treated ALK- cell lines of various histological origins with JAK inhibitors. Interestingly, most exogenous cytokine-independent cell  ...[more]

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