Dataset Information


Mus musculus

ABSTRACT: Time-course analysis of astrocyte-specific RNA-seq in two severities of spinal cord injury

ORGANISM(S): Mus musculus  



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Spinal cord injury induces astroglial conversion towards neuronal lineage.

Noristani Harun Najib HN   Sabourin Jean Charles JC   Boukhaddaoui Hassan H   Chan-Seng Emilie E   Gerber Yannick Nicolas YN   Perrin Florence Evelyne FE  

Molecular neurodegeneration 20161006 1

Neurons have intrinsic capability to regenerate after lesion, though not spontaneously. Spinal cord injury (SCI) causes permanent neurological impairments partly due to formation of a glial scar that is composed of astrocytes and microglia. Astrocytes play both beneficial and detrimental roles on axonal re-growth, however, their precise role after SCI is currently under debate.We analyzed molecular changes in astrocytes at multiple stages after two SCI severities using cell-specific transcriptom  ...[more]

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