Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA378764 | ENA |

REPOSITORIES: ENA

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Publications

Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer.

Sarhan Dhifaf D   Leijonhufvud Caroline C   Murray Shannon S   Witt Kristina K   Seitz Christina C   Wallerius Majken M   Xie Hanjing H   Ullén Anders A   Harmenberg Ulrika U   Lidbrink Elisabet E   Rolny Charlotte C   Andersson John J   Lundqvist Andreas A  

Oncoimmunology 20170614 8


Regulatory T cells (Treg) suppress anti-tumor immune responses and their infiltration in the tumor microenvironment is associated with inferior prognosis in cancer patients. Thus, in order to enhance anti-tumor immune responses, selective depletion of Treg is highly desired. We found that treatment with zoledronic acid (ZA) resulted in a selective decrease in the frequency of Treg that was associated with a significant increase in proliferation of T cells and natural killer (NK) cells in periphe  ...[more]

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