Genomics

Dataset Information

118

Mus musculus


ABSTRACT: ZFP36 RNA binding proteins restrain T-cell activation and anti-viral immunity [HITS-CLIP]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA378770 | ENA |

REPOSITORIES: ENA

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Publications


Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is critical during immune response. ZFP36 RBPs are prominent inflammatory regulators linked to autoimmunity and cancer, but functions in adaptive immunity are less clear. We used HITS-CLIP to define ZFP36 targets in mouse T cells, revealing unanticipated actions in regulating T-cell activation, proliferation, and effector functions. Transcriptome and ribosome profiling showed that ZFP36 represses mRNA target ab  ...[more]

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