Genomics

Dataset Information

238

Mus musculus


ABSTRACT: The RNA-binding protein Sfpq regulates long neuronal genes in transcriptional elongation [N2A_SFPQ_CLIP-seq]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA378774 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


Genes specifically expressed in neurons contain members with extended long introns. Longer genes present a problem with respect to fulfilment of gene length transcription, and evidence suggests that dysregulation of long genes is a mechanism underlying neurodegenerative and psychiatric disorders. Here, we report the discovery that RNA-binding protein Sfpq is a critical factor for maintaining transcriptional elongation of long genes. We demonstrate that Sfpq co-transcriptionally binds to long int  ...[more]

Similar Datasets

| PRJNA378773 | ENA
| PRJNA378772 | ENA
| GSE96081 | GEO
| GSE96080 | GEO
| GSE96082 | GEO
| GSE60241 | GEO
| GSE60238 | GEO
| GSE89031 | GEO
| GSE89032 | GEO
2018-04-18 | MSV000082283 | Massive