Dataset Information


Rattus norvegicus

ABSTRACT: Global gene expression profiling of radiation-induced rat mammary carcinomas

ORGANISM(S): Rattus norvegicus  



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Epigenetic dysregulation of key developmental genes in radiation-induced rat mammary carcinomas.

Daino Kazuhiro K   Nishimura Mayumi M   Imaoka Tatsuhiko T   Takabatake Masaru M   Morioka Takamitsu T   Nishimura Yukiko Y   Shimada Yoshiya Y   Kakinuma Shizuko S  

International journal of cancer 20180223 2

With the increase in the number of long-term cancer survivors worldwide, there is a growing concern about the risk of secondary cancers induced by radiotherapy. Epigenetic modifications of genes associated with carcinogenesis are attractive targets for the prevention of cancer owing to their reversible nature. To identify genes with possible changes in functionally relevant DNA methylation patterns in mammary carcinomas induced by radiation exposure, we performed microarray-based global DNA meth  ...[more]

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