Dataset Information


Homo sapiens

ABSTRACT: Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties

ORGANISM(S): Homo sapiens  



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Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties.

Tome-Garcia Jessica J   Tejero Rut R   Nudelman German G   Yong Raymund L RL   Sebra Robert R   Wang Huaien H   Fowkes Mary M   Magid Margret M   Walsh Martin M   Silva-Vargas Violeta V   Zaslavsky Elena E   Friedel Roland H RH   Doetsch Fiona F   Tsankova Nadejda M NM  

Stem cell reports 20170420 5

Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR+/- populations from human germinal matrix (GM) and adult subventricular zone autopsy tissues, and from de novo glioblastoma (GBM) resections, enriching for cells capable of binding EGF ligand (LBEGFR+), and uniquely compared their functional and molecular properties. LBEGFR+ populations i  ...[more]

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