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AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE)

ABSTRACT: AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE)

PROVIDER: PRJNA380293 | ENA |

REPOSITORIES: ENA

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Homo sapiens

Project description:AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE)

| PRJNA380294 | ENA

AACR Project GENIE

Project description:<p>AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE) is an international pancancer registry of real-world data assembled through data sharing between 19 leading international cancer centers with the goal of improving clinical decision-making. The registry leverages ongoing clinical sequencing efforts (CLIA/ISO-certified) at participating cancer centers by pooling their data to create a novel, open-access registry to serve as an evidence base for the entire cancer community. Genomic and baseline clinical data from more than 70,000 tumors is accessible through the efforts of our strategic and technical partners, Sage Bionetworks and cBioPortal. The consortium and its activities are driven by openness, transparency, and inclusion to ensure that the project output remains accessible to the global cancer research community and ultimately benefits patients.</p>

| phs001337 | dbGaP

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions

Project description:Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions

| PRJNA649800 | ENA

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [an3]

Project description:Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [an3]

| PRJNA649798 | ENA

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [w5C6]

Project description:Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [w5C6]

| PRJNA649805 | ENA

Evaluation of evidence-based patient information on colorectal cancer screening

Project description:Study hypothesis: Evidence-based patient information leads to more informed choices in colorectal cancer screening than traditional information. Primary outcome(s): Informed choice, consisting of the following three dimensions: 1. Knowledge 2. Uptake of colorectal cancer screening 3. Attitude towards colorectal cancer screening Informed choice is measured using the validated questionnaire "Measure of Informed Choice" 6 weeks after the intervention has been provided. Added as of 05/03/2009: Data analyses of knowledge, attitude and uptake questionnaires will be performed according to a predefined coding guide, which has been deposited at a staff member not involved in the study. Data entry and analyses will be carried out blinded.

| 2418251 | ecrin-mdr-crc

Cervical neoplasia genomes

Project description:Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is premalignant lesions of the cervical squamous cell carcinoma (CSCC) that shows abnormal growth of squamous cells in the cervix epithelium. Given the evidence suggesting that differences may exist between CIN and CSCC, we hypothesize that progression may be mediated by subpopulation selection or by acquisition of additional alterations, including gene mutations or chromosomal alterations. In this study, we analyzed cervical CIN, microinvasive carcinoma (MIC) and CSCC by whole-exome sequencing and array-comparative genomic hybridization (array-CGH) and found that CIN genomes harbored fewer mutations (especially fewer driver mutations) and copy number alterations (CNAs), suggesting that additional genomic alterations might burst onto the CIN genome at the final stage of CIN progression to CSCC or an early stage of CSCC.

2014-12-31 | GSE60067 | GEO

Histone Exchange is Associated with Activator Function at Transcribed Promoters and with Repression at Histone Loci

Project description:Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator binding, preinitiation complex (PIC) assembly, and/or subsequent transcription remains unclear. Here, we provide evidence that histone exchange at gene promoters is not simply a consequence of PIC assembly or transcription but instead is mediated by activators. We further show that not all activators up-regulate gene expression by inducing histone turnover. Thus, histone exchange does not simply correlate with transcriptional activity, but instead reflects the mode of action of the activator. Last, we show that histone turnover is not only associated with activator function but also plays a role in transcriptional repression at the histone loci.

2020-01-09 | GSE143305 | GEO

Nucleosome exchange in budding yeast

Project description:Nucleosome exchange in budding yeast

| PRJNA661212 | ENA

Nucleosome exchange in budding yeast

Project description:Measuring nucleosome exchange of all four histone core subunits using novel sensors in budding yeast

2021-06-24 | GSE157402 | GEO