Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA381445 | ENA |

REPOSITORIES: ENA

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Publications

Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions.

Nikolaou Kostas C KC   Moulos Panagiotis P   Harokopos Vangelis V   Chalepakis George G   Talianidis Iannis I  

Cell reports 20170701 4


H4K20 monomethylation maintains genome integrity by regulating proper mitotic condensation, DNA damage response, and replication licensing. Here, we show that, in non-dividing hepatic cells, H4K20Me1 is specifically enriched in active gene bodies and dynamically regulated by the antagonistic action of Kmt5a methylase and Kdm7b demethylase. In liver-specific Kmt5a-deficient mice, reduced levels of H4K20Me1 correlated with reduced RNA Pol II release from promoter-proximal regions. Genes regulating  ...[more]

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