Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: RNA-seq analysis in knockdown Jurkat samples for each factor of TAL1 complex

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA382151 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5440920_1.fastq.gz Fastqsanger.gz
SRR5440920_2.fastq.gz Fastqsanger.gz
SRR5440921_1.fastq.gz Fastqsanger.gz
SRR5440921_2.fastq.gz Fastqsanger.gz
SRR5440912_1.fastq.gz Fastqsanger.gz
Items per page:
1 - 5 of 36
altmetric image

Publications

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.

Leong Wei Zhong WZ   Tan Shi Hao SH   Ngoc Phuong Cao Thi PCT   Amanda Stella S   Yam Alice Wei Yee AWY   Liau Wei-Siang WS   Gong Zhiyuan Z   Lawton Lee N LN   Tenen Daniel G DG   Sanda Takaomi T  

Genes & development 20171201 23-24


The oncogenic transcription factor <i>TAL1/SCL</i> induces an aberrant transcriptional program in T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are directly activated by TAL1 and contribute to T-ALL pathogenesis are largely unknown. Here, we identified <i>AT-rich interactive domain 5B</i> (<i>ARID5B</i>) as a collaborating oncogenic factor involved in the transcriptional program in T-ALL. <i>ARID5B</i> expression is down-regulated at the double-negative 2-  ...[more]

Similar Datasets

2018-01-12 | GSE97513 | GEO
1000-01-01 | S-EPMC1895859 | BioStudies
2012-08-16 | E-GEOD-29181 | ArrayExpress
1000-01-01 | S-EPMC3985645 | BioStudies
2014-01-01 | S-EPMC4248312 | BioStudies
2015-08-14 | GSE66013 | GEO
2012-01-01 | S-EPMC3510314 | BioStudies
2012-08-16 | E-GEOD-29179 | ArrayExpress
| GSE29179 | GEO
1000-01-01 | S-EPMC5889486 | BioStudies