Dataset Information


Homo sapiens

ABSTRACT: RNA-seq analysis in knockdown Jurkat samples for each factor of TAL1 complex

ORGANISM(S): Homo sapiens  



Dataset's files

Action DRS
SRR5440920_1.fastq.gz Fastqsanger.gz
SRR5440920_2.fastq.gz Fastqsanger.gz
SRR5440921_1.fastq.gz Fastqsanger.gz
SRR5440921_2.fastq.gz Fastqsanger.gz
SRR5440912_1.fastq.gz Fastqsanger.gz
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ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.

Leong Wei Zhong WZ   Tan Shi Hao SH   Ngoc Phuong Cao Thi PCT   Amanda Stella S   Yam Alice Wei Yee AWY   Liau Wei-Siang WS   Gong Zhiyuan Z   Lawton Lee N LN   Tenen Daniel G DG   Sanda Takaomi T  

Genes & development 20171201 23-24

The oncogenic transcription factor <i>TAL1/SCL</i> induces an aberrant transcriptional program in T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are directly activated by TAL1 and contribute to T-ALL pathogenesis are largely unknown. Here, we identified <i>AT-rich interactive domain 5B</i> (<i>ARID5B</i>) as a collaborating oncogenic factor involved in the transcriptional program in T-ALL. <i>ARID5B</i> expression is down-regulated at the double-negative 2-  ...[more]

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