Project description:Analysis of gene expression in macrophages infected with influenza A virus or Mock and treated with the VX-787 to investigate the effects VX-787 have on transcriptional response in human macrophages. Human macrophages were infected with influenza A/WSN/1933(H1N1) or A/Udorn/307/72(H3N2) viruses, or non-infected (Mock). 10nM VX-787 was treated to WSN, Udorn or Mock infected cells, repectively.
Project description:We used the microarray data to analyse the host cell responses on mouse macrophages infected with the three Influenza A viruses The global expression analysis showed increased expression changes in H5N3 infected mouse macrophages compared to H5N2/F118 and H1N1/WSN
