Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to ROS augmenting agents

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA384369 | ENA |

REPOSITORIES: ENA

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Publications

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent.

Wang Tingting T   Liu Lingling L   Chen Xuyong X   Shen Yuqing Y   Lian Gaojian G   Shah Nilay N   Davidoff Andrew M AM   Yang Jun J   Wang Ruoning R  

Cell death & disease 20180214 2


Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of MYCN, a member of the Myc oncogene family that is primarily expressed in the early stage of embryonic development and required for neural crest development. Here we report that an enriched glutaminolysis gene signature is associated with MYCN amplification in children with NBL. The partial k  ...[more]

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