Genomics

Dataset Information

0

Mus musculus


ABSTRACT: A new HDV mouse model showing important features of human infection and identifying MAVS as a key player in IFN-β induction

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA384783 | ENA |

REPOSITORIES: ENA

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Publications


<h4>Background & aims</h4>Studying hepatitis delta virus (HDV) and developing new treatments is hampered by the limited availability of small animal models. Herein, a description of a robust mouse model of HDV infection that mimics several important characteristics of the human disease is presented.<h4>Methods</h4>HDV and hepatitis B virus (HBV) replication competent genomes were delivered to the mouse liver using adeno-associated viruses (AAV; AAV-HDV and AAV-HBV). Viral load, antigen expressio  ...[more]

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