Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Activation of LINE-1 after fertilisation regulates global chromatin accessibility

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA385089 | ENA |

REPOSITORIES: ENA

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Publications

LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo.

Jachowicz Joanna W JW   Bing Xinyang X   Pontabry Julien J   Bošković Ana A   Rando Oliver J OJ   Torres-Padilla Maria-Elena ME  

Nature genetics 20170828 10


After fertilization, to initiate development, gametes are reprogramed to become totipotent. Approximately half of the mammalian genome consists of repetitive elements, including retrotransposons, some of which are transcribed after fertilization. Retrotransposon activation is generally assumed to be a side effect of the extensive chromatin remodeling underlying the epigenetic reprogramming of gametes. Here, we used a targeted epigenomic approach to address whether specific retrotransposon famili  ...[more]

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