Genomics

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Gene Expression and SNP genotype data from induced Pluripotent Stem cells from healthy control donors


ABSTRACT: Gene Expression and SNP genotype data from induced Pluripotent Stem cells from healthy control donors

PROVIDER: PRJNA387377 | ENA |

REPOSITORIES: ENA

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Publications

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Beevers Joel E JE   Lai Mang Ching MC   Collins Emma E   Booth Heather D E HDE   Zambon Federico F   Parkkinen Laura L   Vowles Jane J   Cowley Sally A SA   Wade-Martins Richard R   Caffrey Tara M TM  

Stem cell reports 20170706 2


The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be fully elucidated. Here, we employ extended maturation phases during differentiation of induced pluripotent stem cells (iPSCs) into mature dopaminergic neuronal cultures to obtain cultures expressing all s  ...[more]

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