Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lacticaseibacillus rhamnosus strain:4B15

ABSTRACT: Lacticaseibacillus rhamnosus strain:4B15 Genome sequencing

PROVIDER: PRJNA387641 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Probiotic Lacticaseibacillus rhamnosus HA-114 suppresses age-dependent neurodegeneration via mitochondrial beta-oxidation

Project description:The human microbiota is believed to influence health. Microbiome dysbiosis may be linked to neurological conditions like Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). We report the ability of a probiotic bacterial strain in halting neurodegeneration phenotypes. We show that Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of ALS and HD. Our results show that neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains, and resides in its fatty acid content. Neuroprotection by L. rhamnosus HA-114 requires acdh-1/ACADSB, kat-1/ACAT1 and elo-6/ELOVL3/6, which are key fatty acid metabolism and mitochondrial b-oxidation genes. Our data suggest that disrupted lipid metabolism contributes to neurodegeneration and that dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial b-oxidation. L. rhamnosus HA-114 is suitable for human consumption opening the possibility of modifying disease progression by dietary intervention.

2021-12-05 | GSE189988 | GEO

Lacticaseibacillus rhamnosus

Project description:Lacticaseibacillus rhamnosus Genome sequencing

| PRJNA717401 | ENA

Lacticaseibacillus rhamnosus

Project description:Lacticaseibacillus rhamnosus Genome sequencing

| PRJNA481623 | ENA

Lacticaseibacillus rhamnosus strain:LDTM7511

Project description:Lacticaseibacillus rhamnosus strain:LDTM7511 Genome sequencing

| PRJNA623728 | ENA

Lacticaseibacillus rhamnosus strain:PMC203

Project description:Lacticaseibacillus rhamnosus strain:PMC203 Genome sequencing

| PRJNA776987 | ENA

Lacticaseibacillus rhamnosus strain:DM065

Project description:Lacticaseibacillus rhamnosus strain:DM065 Genome sequencing

| PRJNA851917 | ENA

Lacticaseibacillus rhamnosus strain:BFE5264

Project description:Lacticaseibacillus rhamnosus strain:BFE5264 Genome sequencing

| PRJNA308635 | ENA

Lacticaseibacillus rhamnosus strain:P118

Project description:Lacticaseibacillus rhamnosus strain:P118 Genome sequencing

| PRJNA848987 | ENA

Lacticaseibacillus rhamnosus strain:X253

Project description:Lacticaseibacillus rhamnosus strain:X253 Genome sequencing

| PRJNA725026 | ENA

Lacticaseibacillus rhamnosus strain:LV108

Project description:Lacticaseibacillus rhamnosus strain:LV108 Genome sequencing

| PRJNA633420 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data