Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: ARS2 is a general suppressor of pervasive transcription

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA388166 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5616060_1.fastq.gz Fastqsanger.gz
SRR5616060_2.fastq.gz Fastqsanger.gz
SRR5616070_1.fastq.gz Fastqsanger.gz
SRR5616070_2.fastq.gz Fastqsanger.gz
SRR5616080_1.fastq.gz Fastqsanger.gz
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Publications


Termination of transcription is important for establishing gene punctuation marks. It is also critical for suppressing many of the pervasive transcription events occurring throughout eukaryotic genomes and coupling their RNA products to efficient decay. In human cells, the ARS2 protein has been implicated in such function as its depletion causes transcriptional read-through of selected gene terminators and because it physically interacts with the ribonucleolytic nuclear RNA exosome. Here, we stu  ...[more]

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