Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Nup153 defines neural identity through cooperative transcriptional control with Sox2

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA389588 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda Tomohisa T   Hsu Jonathan Y JY   Linker Sara B SB   Hu Lauren L   Schafer Simon T ST   Mertens Jerome J   Jacinto Filipe V FV   Hetzer Martin W MW   Gage Fred H FH  

Cell stem cell 20170914 5


Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differen  ...[more]

Similar Datasets

2018-08-27 | E-MTAB-6348 | ArrayExpress
| PRJNA270996 | ENA
2009-05-20 | GSE16139 | GEO
| GSE101529 | GEO
2011-01-06 | GSE21746 | GEO
2013-05-10 | E-GEOD-46796 | ArrayExpress
2009-05-20 | E-GEOD-16139 | ArrayExpress
2004-01-02 | GSE887 | GEO
2014-12-04 | E-GEOD-61417 | ArrayExpress
2008-11-25 | BIOMD0000000203 | BioModels