Dataset Information


Mus musculus

ABSTRACT: Nup153 defines neural identity through cooperative transcriptional control with Sox2

ORGANISM(S): Mus musculus  



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Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda Tomohisa T   Hsu Jonathan Y JY   Linker Sara B SB   Hu Lauren L   Schafer Simon T ST   Mertens Jerome J   Jacinto Filipe V FV   Hetzer Martin W MW   Gage Fred H FH  

Cell stem cell 20170914 5

Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differen  ...[more]

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