Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Astrocyte-enriched pan-brain aging transcriptome

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA389601 | ENA |

REPOSITORIES: ENA

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Publications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain.

Boisvert Matthew M MM   Erikson Galina A GA   Shokhirev Maxim N MN   Allen Nicola J NJ  

Cell reports 20180101 1


Aging brains undergo cognitive decline, associated with decreased neuronal synapse number and function and altered metabolism. Astrocytes regulate neuronal synapse formation and function in development and adulthood, but whether these properties change during aging, contributing to neuronal dysfunction, is unknown. We addressed this by generating aged and adult astrocyte transcriptomes from multiple mouse brain regions. These data provide a comprehensive RNA-seq database of adult and aged astroc  ...[more]

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