Genomics

Dataset Information

235

Mus musculus


ABSTRACT: Astrocyte-specific and region-specific transcriptomes in control and EAE mice: optic nerve

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA391269 | ENA |

REPOSITORIES: ENA

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Publications

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes.

Itoh Noriko N   Itoh Yuichiro Y   Tassoni Alessia A   Ren Emily E   Kaito Max M   Ohno Ai A   Ao Yan Y   Farkhondeh Vista V   Johnsonbaugh Hadley H   Burda Josh J   Sofroniew Michael V MV   Voskuhl Rhonda R RR  

Proceedings of the National Academy of Sciences of the United States of America 20171226 2


Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from one CNS region to another and are complicated by alterations in cellular composition during disease. Multiple sclerosis (MS) is multifocal by definition. Here, a cell-specific and region-specific transcriptomics approach was used to determine gene expression changes in astrocytes in the most widely used MS model, experimental autoimmune en  ...[more]

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