Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells

PROVIDER: PRJNA392693 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR5790200.fastq.gz Fastqsanger.gz
SRR5790210.fastq.gz Fastqsanger.gz
SRR5790201.fastq.gz Fastqsanger.gz
SRR5790211.fastq.gz Fastqsanger.gz
SRR5790202.fastq.gz Fastqsanger.gz
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Publications

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.

Villarino Alejandro V AV   Sciumè Giuseppe G   Davis Fred P FP   Iwata Shigeru S   Zitti Beatrice B   Robinson Gertraud W GW   Hennighausen Lothar L   Kanno Yuka Y   O'Shea John J JJ  

The Journal of experimental medicine 20170915 10


Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of all known ILC subsets in mice and reveal a hierarchy of STAT5 dependency for populating lymphoid and nonlymphoid tissues. We apply transcriptome and genomic distribution analyses to define a STAT5 gene signature in natural killer (NK) cells, the  ...[more]

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