Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Global analysis of gene expression changes following LINE1 inhibition

ABSTRACT: Global analysis of gene expression changes following LINE1 inhibition

PROVIDER: PRJNA393455 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Global analysis of gene expression changes following LINE1 inhibition [III]

Project description:Global analysis of gene expression changes following LINE1 inhibition [III]

| PRJNA437623 | ENA

Global analysis of gene expression changes following LINE1 inhibition [III]

Project description:Transposable elements make up nearly half of mammalian genomes, yet are generally described as ‘junk DNA’ or genome parasites. The LINE1 retrotransposon is the most abundant class and is thought to be deleterious for cells, but it is paradoxically expressed at high levels during early development. Here, we report that LINE1 plays essential roles in mouse embryonic stem (ES) cells and pre-implantation embryos. In ES cells, LINE1 acts as a nuclear RNA scaffold that recruits Nucleolin and Kap1/Trim28 to repress Dux, the master activator of a gene expression program specific to the 2-cell stage. In parallel, LINE1 RNA mediates binding of Nucleolin and Kap1 to rDNA, thereby promoting rRNA synthesis and ES cell self-renewal. In embryos, LINE1 RNA is required for silencing of Dux, proper synthesis of rRNA and exit from the 2-cell stage. These results reveal an essential partnership between nuclear LINE1 RNA and chromatin factors in the regulation of transcription, developmental potency and ES cell self-renewal.

2018-06-30 | GSE111633 | GEO

Global analysis of gene expression changes following LINE1 inhibition [I]

2018-06-30 | GSE100937 | GEO

Global analysis of gene expression changes following LINE1 inhibition [II]

2018-06-30 | GSE100938 | GEO

Global Changes following N-deprivation in Chlamydomonas

Project description:Global Changes following N-deprivation in Chlamydomonas

| PRJNA132829 | ENA

Gene expression changes in REH following CDC42 inhibition

Project description:Gene expression changes in REH following CDC42 inhibition

| PRJNA640612 | ENA

Mus musculus

Project description:Global analysis of gene expression changes following LINE1 inhibition [II]

| PRJNA393460 | ENA

Mus musculus

Project description:Global analysis of gene expression changes following LINE1 inhibition [I]

| PRJNA393461 | ENA

Global analysis of gene expression changes following LINE1 inhibition

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-30 | GSE100939 | GEO

RNA expression changes in MDA-MB-231 cells following MEK inhibition

Project description:Molecular responses to MEK inhibition in cancer cells are complex and dynamic. We performed a time-series experiment to measure global RNA expression changes following treatment with the MEK inihibor U0126

2015-04-01 | GSE61364 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data